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Updated: Dec 23, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Tetrameric PKM2 Activation Curbs CD4+ T Cell Overactivation

Shuai Jiang1

  • 1Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

Trends in Endocrinology and Metabolism: TEM
|April 29, 2020
PubMed
Summary

TEPP-46 inhibits CD4+ T cell activation and development by inducing PKM2 tetramerization, suppressing its nuclear translocation and T cell glycolysis. This suggests PKM2 tetramerization is a promising therapeutic target for autoimmune diseases like EAE.

Keywords:
CD4(+) T cellPKM2 tetramerizationTEPP-46

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