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Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety
N N Dygalo1,2, D A Lanshakov3, N P Komysheva3
1Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia. dygalo@bionet.nsc.ru.
Doklady. Biochemistry and Biophysics
|April 29, 2020
Abstract:
Abstract-Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.
