Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

24.4K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.4K
Alternative RNA Splicing02:18

Alternative RNA Splicing

4.6K
4.6K
RNA Splicing01:32

RNA Splicing

60.1K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.1K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

8.0K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.0K
What is Gene Expression?01:36

What is Gene Expression?

10.5K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
10.5K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

8.0K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphoproteomic Analysis of Cortical Tissue from Mice Lacking Both CaMKIIα and CaMKIIβ Identifies Novel In Vivo Substrates.

ACS chemical neuroscience·2026
Same author

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.

Nature communications·2025
Same author

Bacterial ubiquitin ligase engineered for small molecule and protein target identification.

bioRxiv : the preprint server for biology·2025
Same author

Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.

Nature communications·2025
Same author

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.

Protein science : a publication of the Protein Society·2024
Same author

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Dec 23, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.2K

Functional implications of CaMKII alternative splicing.

Roman Sloutsky1, Margaret M Stratton1

  • 1Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.

The European Journal of Neuroscience
|April 29, 2020
PubMed
Summary

Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a key role in memory formation. This review proposes a new naming system for CaMKII variants to address current ambiguity and discuss their biological implications.

Keywords:
CaMKIIalternative splicingcalcium-dependent kinasesplice variants

More Related Videos

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

6.2K
Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.3K

Related Experiment Videos

Last Updated: Dec 23, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.2K
Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

6.2K
Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.3K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Calcium/calmodulin-dependent protein kinase II (CaMKII) is vital for synaptic plasticity and memory.
  • CaMKII is encoded by four human genes, with alternative splicing creating diverse protein variants.
  • Recent sequencing advances have identified numerous new CaMKII transcripts.

Purpose of the Study:

  • To review the history of CaMKII discovery and its variants.
  • To propose a standardized, unambiguous nomenclature for CaMKII splice variants.
  • To discuss the biological significance of different CaMKII variants.

Main Methods:

  • Literature review of CaMKII research.
  • Analysis of existing CaMKII transcript nomenclature.
  • Synthesis of data to propose a new naming scheme.

Main Results:

  • Current CaMKII transcript naming is inconsistent and ambiguous.
  • A need exists for a clear, systematic nomenclature.
  • The review provides a historical context and proposes a new naming convention.

Conclusions:

  • A standardized naming scheme for CaMKII variants is crucial for clear communication and future research.
  • Understanding CaMKII splice variant diversity is essential for deciphering its role in neurological functions.
  • The proposed nomenclature aims to facilitate research into CaMKII's molecular, cellular, and organismic roles in memory.