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The relation of endocan and galectin-3 with ST-segment resolution in patients with ST-segment elevation myocardial

Yaşar Turan1, Vahit Demir1

  • 1Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|April 29, 2020
PubMed

Insights

Endocan and galectin-3 levels may predict poor ST-segment resolution (STR) after primary percutaneous coronary intervention (PPCI) in ST-segment elevation myocardial infarction (STEMI) patients. Higher levels indicate increased risk of insufficient myocardial perfusion and worse outcomes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Myocardial Infarction Research

Background:

  • ST-segment elevation myocardial infarction (STEMI) is a major global health concern.
  • ST-segment resolution (STR) after primary percutaneous coronary intervention (PPCI) is a key indicator of myocardial perfusion and prognosis in STEMI.
  • Identifying predictors of successful reperfusion is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the association between endocan and galectin-3 levels and ST-segment resolution (STR) in patients with STEMI undergoing PPCI.
  • To determine if these biomarkers can predict incomplete STR and poorer myocardial perfusion.

Main Methods:

  • A cross-sectional study enrolled 98 STEMI patients undergoing PPCI.
  • Patients were categorized into complete STR (≥70%) and incomplete STR (<70%) groups based on electrocardiogram assessments 60 minutes post-PPCI.
  • Serum levels of endocan and galectin-3, along with SYNTAX scores, were analyzed.

Main Results:

  • Patients with incomplete STR exhibited significantly higher levels of glucose, cholesterol, low-density lipoprotein, SYNTAX score, endocan, and galectin-3.
  • Endocan and galectin-3 were identified as independent predictors of incomplete STR.
  • Higher endocan and galectin-3 levels were associated with poorer myocardial perfusion and worse clinical outcomes.

Conclusions:

  • Elevated serum levels of endocan and galectin-3 are associated with incomplete ST-segment resolution in STEMI patients.
  • These biomarkers may serve as valuable tools for identifying patients at higher risk of insufficient myocardial perfusion post-PPCI.
  • Further research can explore therapeutic strategies targeting these markers to improve STEMI patient outcomes.
Abstract

Keywords:
ST-segment elevation myocardial infarctionST-segment resolutionendocangalectin-3

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