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Relationship Between the Systemic Immune-Inflammation Index and Non-Dipper Blood Pressure Status in Normotensive
Elif Turan1, Yaşar Turan2, Mustafa Yolcu3
1Department of Endocrinology, Faculty of Medicine, Samsun University, Samsun, Turkey.
Journal of Clinical Hypertension (Greenwich, Conn.)
|November 30, 2025
Summary
Prediabetes patients with non-dipper blood pressure (BP) show higher inflammation markers, suggesting increased cardiovascular disease risk even without hypertension. This highlights the importance of monitoring BP patterns in prediabetes.
Area of Science:
- Cardiology
- Endocrinology
- Immunology
Background:
- Non-dipper blood pressure (BP) is linked to increased cardiovascular disease (CVD) and organ damage in hypertensive individuals.
- Inflammation is a key factor in atherosclerosis and CVD development.
- Limited data exists on the significance of nighttime BP patterns in normotensive individuals.
Purpose of the Study:
- To investigate the relationship between dipper and non-dipper BP status and inflammatory parameters in normotensive patients with prediabetes.
- To assess potential links between BP dipping status and inflammation in at-risk individuals.
Main Methods:
- Cross-sectional study design.
- Inclusion of 208 normotensive prediabetic individuals, categorized into dipper (90) and non-dipper (118) BP groups.
- Collection of peripheral venous blood samples for analysis of inflammatory markers.
Main Results:
- No significant differences in baseline clinical characteristics between the dipper and non-dipper groups.
- Significantly higher levels of C-reactive protein (CRP) and systemic immune-inflammation index (SII) in the non-dipper BP group.
- Logistic regression identified SII as independently associated with non-dipper BP status (OR = 1.001, p = 0.017).
Conclusions:
- Non-dipper BP status in prediabetic patients, even when normotensive, may be associated with heightened inflammation.
- This association suggests a potentially increased CVD risk in these individuals.
- Identifying such risk factors is crucial for improving cardiovascular health outcomes in prediabetes.
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