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Updated: Dec 23, 2025

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

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GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508

Safa Lucken-Ardjomande Häsler1, Yvonne Vallis1, Mathias Pasche1

  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

The Journal of Cell Biology
|April 29, 2020
PubMed
Summary

This study reveals that GRAF proteins, alongside MICAL1 and WDR44, mediate alternative exocytosis pathways. These proteins are crucial for exporting specific transmembrane proteins via Rab8, Rab10, and Rab11-dependent routes.

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