Towards restoring proper chromosome segregation and preventing ageing
Laura Tovini1, Sarah E McClelland1
1Barts Cancer Institute, Queen Mary University of London, London, UK.
Abstract:
The natural progressive dysfunction of most living organisms-ageing-has captured the attention of several studies, with the intention to develop rejuvenation strategies. Evidence is emerging of a positive correlation between natural ageing and chromosomal instability (CIN). In this issue of EMBO Reports, Barroso-Vilares et al [1] now show a link between ageing and the erroneous assembly of the apparatus required for a proper cellular division. They compare this mechanism in young and naturally aged human cells and describe a strategy to delay age-related CIN.
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