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miR-22 and cerebral microbleeds in brainstem and deep area are associated with depression one month after ischemic

Jia Hu1, Wei Zhou2, Zhiming Zhou3

  • 1Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 30, 2020
PubMed

Insights

Higher plasma miR-22 levels and deep or brainstem cerebral microbleeds (CMBs) are independent risk factors for post-stroke depression (PSD) one month after ischemic stroke. miR-22 may predict PSD development and is linked to cerebral microvascular impairment.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Post-stroke depression (PSD) is a common complication following ischemic stroke, significantly impacting patient recovery and quality of life.
  • Cerebral microbleeds (CMBs), particularly deep and brainstem microbleeds, are increasingly recognized as potential contributors to neurological and psychological deficits after stroke.
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various biological processes, including neurological disorders.

Purpose of the Study:

  • To investigate the association between plasma miR-22 levels, the presence of deep and brainstem CMBs, and the occurrence of PSD one month after acute ischemic stroke.
  • To identify independent risk factors for PSD in patients with acute cerebral infarction.
  • To evaluate the predictive value of plasma miR-22 for PSD development.

Main Methods:

  • A cohort of 257 patients with first-ever or recurrent acute cerebral infarction were recruited.
  • Diagnosis of PSD was performed using the Diagnostic and Statistical Manual IV criteria.
  • Plasma miR-22 levels were quantified using quantitative PCR, and associations with clinical data, CMBs, and PSD were analyzed using logistic regression and receiver operating curve analysis.

Main Results:

  • Deep CMBs (OR=1.845) and brainstem CMBs (OR=2.652) were identified as independent risk factors for PSD.
  • Elevated plasma miR-22 levels (OR=2.094) were also found to be an independent risk factor for PSD.
  • Receiver operating curve analysis indicated that miR-22 has predictive value for PSD (AUC=0.723, P=0.016).
  • Plasma miR-22 levels showed an upward trend in patients with brainstem and deep CMBs (P=0.028).

Conclusions:

  • Plasma miR-22 levels and the presence of deep or brainstem CMBs are significant independent risk factors for developing PSD one month post-ischemic stroke.
  • miR-22 may play a role in the pathophysiology of cerebral microvascular impairment and PSD.
  • These findings suggest miR-22 as a potential biomarker for predicting PSD in stroke patients.

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