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Related Experiment Video

Updated: Dec 23, 2025

Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

Single-shot ultrafast imaging attaining 70 trillion frames per second.

Peng Wang¹, Jinyang Liang^1,2, Lihong V Wang³

¹Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Mail Code 138-78, Pasadena, CA, 91125, USA.

Nature Communications

|May 1, 2020

Summary

This summary is machine-generated.

Compressed Ultrafast Spectral Photography (CUSP) achieves record speeds for single-shot imaging, capturing ultrafast dynamics. This breakthrough enables real-time, multi-dimensional scientific studies without repeating events.

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Last Updated: Dec 23, 2025

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Area of Science:

Physics
Optics
Spectroscopy

Background:

Current femtosecond imaging lacks the speed and frame count for real-time dynamics.
Existing methods are limited to 10^13 fps and 300 frames, often requiring event repetition.

Purpose of the Study:

To develop a novel imaging technique surpassing current speed and frame limitations.
To enable real-time, quantitative, multi-dimensional imaging of ultrafast phenomena.

Main Methods:

Compressed Ultrafast Spectral Photography (CUSP) combines spectral encoding, pulse splitting, temporal shearing, and compressed sensing.
Active mode: 7x10^13 fps and 1000 frames for nonlinear light-matter interactions.
Passive mode: 0.5x10^12 fps for 4D spectral imaging, including SR-FLIM.

Main Results:

CUSP achieves record-breaking single-shot imaging speeds and frame counts.
Demonstrates unprecedented quantitative imaging of rapid nonlinear light-matter interactions.
Enables the first single-shot spectrally resolved fluorescence lifetime imaging microscopy (SR-FLIM).

Conclusions:

CUSP is a groundbreaking real-time multi-dimensional imaging technology.
Its high speed and frame count overcome limitations of existing modalities.
CUSP will significantly advance scientific studies requiring the observation of rapid dynamics without event repetition.