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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
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Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria
Hadyn L Parker1, Ruben M F Tomás, Christopher M Furze
1School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. e.fullam@warwick.ac.uk.
Organic & Biomolecular Chemistry
|May 1, 2020
Abstract:
The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

