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Updated: Dec 22, 2025

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Rare Case of Diffuse Splenic Uptake on Methylene Diphosphonate Bone Scan in a Patient with Sickle Cell Disease
Girish Kumar Parida1, Sujata Mitra1, Gopal Sonai Muthu1
1Department of Nuclear Medicine and PET-CT, Tata Main Hospital, Jamshedpur, Jharkhand, India.
Abstract:
Extraskeletal tracer uptake in methylene diphosphonate (MDP) bone scan is not a common finding. There have been several case reports in the literature showing diffuse splenic uptake in MDP bone scan. We present a case of sickle cell disease, which showed diffuse splenic uptake on MDP whole-body bone scan.

