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Impact of 18F-FDG-PET/CT in Managing a Case of Fungal Prosthetic Valve Endocarditis

Komal Bishnoi1, P Sai Sradha Patro1, Girish Kumar Parida1

  • 1All India Institute of Medical Sciences, Department of Nuclear Medicine, Bhubaneswar, India.

Molecular Imaging and Radionuclide Therapy
|March 6, 2026
PubMed

Insights

Fungal prosthetic valve endocarditis is rare but serious. 18F-FDG PET/CT imaging aids in diagnosing and managing this condition, especially in complex cases like Marfan syndrome.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Nuclear Medicine

Background:

  • Fungal endocarditis affects approximately 0.1% of prosthetic cardiac valves.
  • It has a high case fatality rate, and diagnosis can be challenging.
  • Standard diagnostic methods may not definitively rule out residual disease.

Purpose of the Study:

  • To highlight the diagnostic and management role of 18F-FDG PET/CT in fungal prosthetic valve endocarditis.
  • To report a rare case of fungal prosthetic valve endocarditis in a patient with Marfan syndrome.

Main Methods:

  • Review of a rare case involving a patient with Marfan syndrome and fungal prosthetic valve endocarditis.
  • Utilized 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for diagnosis and management decisions.

Main Results:

  • 18F-FDG PET/CT demonstrated high sensitivity, specificity, and accuracy in diagnosing prosthetic valve infective endocarditis.
  • The imaging technique significantly influenced clinical management decisions in the presented case.

Conclusions:

  • 18F-FDG PET/CT is a valuable tool for the diagnosis and follow-up of fungal prosthetic valve endocarditis.
  • This imaging modality played a crucial role in the management of a rare case of fungal prosthetic valve endocarditis in a Marfan syndrome patient.
Keywords:
18F-FDG-PET/CTCandida endocarditisMarfan syndromefungal endocarditisprosthetic valve endocarditis

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