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Enterovirus D68 Antivirals: Past, Present, and Future
Yanmei Hu1, Rami Musharrafieh1, Madeleine Zheng1
1Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
ACS Infectious Diseases
|May 1, 2020
Summary
Enterovirus D68 (EV-D68) causes respiratory illness and acute flaccid myelitis (AFM). This review explores EV-D68
Area of Science:
- Virology
- Neuroscience
- Infectious Diseases
Background:
- Enterovirus D68 (EV-D68) is an RNA virus responsible for respiratory illnesses in children.
- Severe EV-D68 infections can lead to neurological complications, notably acute flaccid myelitis (AFM).
- EV-D68 is part of the Picornaviridae family, which includes other notable human pathogens.
Purpose of the Study:
- To review the current understanding of the EV-D68 and AFM connection.
- To elucidate the mechanisms of EV-D68 replication.
- To summarize recent advancements in developing EV-D68 antivirals.
Main Methods:
- Review of existing literature on EV-D68.
- Analysis of viral replication mechanisms.
- Examination of antiviral strategies targeting viral proteins and host factors.
Main Results:
- The review details the association between EV-D68 and AFM.
- It outlines the molecular mechanisms underlying EV-D68 replication.
- Progress in developing antivirals targeting key viral and host components is presented.
Conclusions:
- There are currently no approved vaccines or antivirals for EV-D68.
- Developing effective EV-D68 antivirals is crucial due to its potential for severe neurological complications.
- Future research directions and clinical trial criteria for EV-D68 antiviral drug discovery are discussed.
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