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Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution
Published on: May 2, 2020
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Advances in Extrusion 3D Bioprinting: A Focus on Multicomponent Hydrogel-Based Bioinks
Xiaolin Cui1,2, Jun Li1, Yusak Hartanto3
1Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, 8011, New Zealand.
Advanced Healthcare Materials
|May 1, 2020
Summary
Multicomponent bioinks are crucial for advancing 3D bioprinting in tissue engineering and regenerative medicine (TERM). This review explores hydrogel-based systems to overcome challenges in creating functional, 3D-printed tissues.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- 3D bioprinting combines 3D printing with cells and biomaterials for tissue engineering and regenerative medicine (TERM).
- Significant challenges remain in translating 3D bioprinting into clinical applications.
- Optimizing cell-laden bioinks for printability and biological function is critical but difficult for single-component systems.
Purpose of the Study:
- To systematically review multicomponent hydrogel-based bioink systems for extrusion-based 3D bioprinting.
- To highlight current advances and applications of these bioinks.
- To identify unmet challenges in the field.
Main Methods:
- Review of recent literature on multicomponent bioinks.
- Classification of bioinks based on natural or synthetic hydrogel components.
- Analysis of bioink properties (rheological, physico-mechanical, biofunctionality) and applications.
Main Results:
- Multicomponent bioinks offer improved printability, shape fidelity, and biofunctionality compared to single-component systems.
- Both natural and synthetic hydrogel-based multicomponent bioinks show promise.
- Recent examples demonstrate enhanced properties and diverse applications in TERM.
Conclusions:
- Multicomponent bioinks are essential for overcoming limitations in current 3D bioprinting technologies.
- Further research is needed to address remaining challenges for clinical translation.
- This review aids researchers in selecting appropriate bioinks and understanding future research directions.
