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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
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Multiple approaches for achieving drug solubility: an in silico perspective
Torsa Das1, Chetan H Mehta1, Usha Y Nayak1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Drug Discovery Today
|May 1, 2020
Summary
Developing new drugs often faces challenges with poor solubility and low bioavailability. This review explores computational methods to understand drug-carrier interactions and enhance solubility, stability, and bioavailability for effective pharmaceutical development.
Area of Science:
- Pharmaceutical Science
- Computational Chemistry
- Drug Delivery
Background:
- Many newly discovered therapeutic molecules are lipophilic, leading to poor aqueous solubility and reduced bioavailability.
- Low solubility necessitates the application of various solubility enhancement techniques in pharmaceutical research.
- Understanding drug-carrier interactions is crucial for improving drug formulation and efficacy.
Purpose of the Study:
- To review computational approaches for analyzing drug-carrier interactions.
- To provide molecular insights into how drug modifiers affect solubility, stability, and bioavailability.
- To highlight research strategies for overcoming poor aqueous solubility in drug development.
Main Methods:
- Review of existing literature on computational approaches in drug solubility enhancement.
- Analysis of molecular interactions between drugs and carriers using computational models.
- Examination of conformational changes in carrier matrices influencing formulation stability.
Main Results:
- Computational methods offer molecular-level understanding of drug-solubility relationships.
- These approaches can predict and optimize drug-carrier interactions for improved stability.
- Insights gained can guide the selection of appropriate solubility enhancement strategies.
Conclusions:
- Computational strategies are vital for unraveling the complexities of drug solubility, stability, and bioavailability.
- Molecular insights from computational studies facilitate the development of more effective drug formulations.
- This review underscores the importance of computational approaches in modern pharmaceutical research and development.
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