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Published on: May 17, 2019
Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan
Chin-Nan Chu1,2, Yun-Chi Wang3, Wen-Shin Chang3
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
Background/Aim:
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese.
Materials And Methods:
A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.
Results:
Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls.
Conclusion:
IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese.
