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The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines.

Nitija Tiwari1, Marisa López-Redondo2,3, Laura Miguel-Romero2,3

  • 1Department of Biochemistry, University of Iowa, Iowa City, IA 52242.

Proceedings of the National Academy of Sciences of the United States of America
|May 2, 2020
PubMed
Summary

The SrrAB two-component system (TCS) regulates Staphylococcus aureus virulence. A unique disulfide bond in SrrB senses redox signals, controlling bacterial survival and pathogenesis during infection.

Keywords:
SrrAB two-component systemStaphylococcus aureuscysteine disulfide bondsensor histidine kinase

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