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Reversed-phase ion-pair liquid chromatographic method for the determination of low concentrations of haloperidol in
1Astra Research Center, Södertälje, Sweden.
Journal of Chromatography
|September 23, 1988
Abstract:
A sensitive liquid chromatographic method for the determination of haloperidol in plasma is described. The efficient and simple extraction procedure, followed by reversed-phase ion-pair liquid chromatography on a 3-micron octadecylsilica column and UV absorbance detection, makes it possible to determine concentrations down to 0.5 nmol/l with acceptable precision. In a pharmacokinetic study, in which 5 mg of haloperidol were given orally, the plasma levels were followed for 48 h.