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Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

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Development and Validation of a MATLAB Software Program for Decoding the Treatment Errors in Real-time Position

Naveen Kumawat¹, Anil Kumar Shrotriya², Malhotra Singh Heigrujam¹

¹Deparment of Radiation Oncology, Max Super Speciality Hospital, New Delhi, India.

Journal of Medical Physics

|May 2, 2020

Summary

A new MATLAB program quantifies "beam-on" errors in Real-time Position Management (RPM) breathing traces, showing errors under 1.5%. This tool aids in accurate radiation therapy delivery by analyzing intrafraction motion during treatment.

Keywords:

Beam-on errors MATLAB breathing trace gating time delay

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Area of Science:

Medical Physics
Radiation Oncology
Software Development

Background:

Real-time Position Management (RPM) is crucial for reducing normal tissue complications during radiation therapy.
Currently, no commercial software exists to quantify "beam-on" errors in RPM-generated breathing traces.
Accurate quantification of these errors is essential for improving treatment precision.

Purpose of the Study:

To develop and validate an in-house MATLAB program for quantifying "beam-on" errors in breathing traces.
To assess the accuracy of the developed program using phantoms and patient data.
To provide a tool for analyzing intrafraction motion during radiation therapy.

Main Methods:

A graphical user interface (GUI) was developed using MATLAB software.
The GUI was validated with two phantoms (Varian-gated and Brainlab ET gating) and regular motion profiles.
Irregular breathing profiles from ten patients were analyzed using the GUI.

Main Results:

Beam-on errors (time and displacement) were consistently below 1.5% for phase- and amplitude-based treatments.
The average treatment time delay was measured at 47 ± 0.003 ms.
Amplitude-based gating demonstrated higher accuracy than phase-based gating for irregular breathing patterns.

Conclusions:

The developed MATLAB GUI provides accurate and acceptable results for quantifying "beam-on" errors.
The program effectively analyzes intrafraction errors in breathing traces for both phase- and amplitude-based gating techniques.
The software can convert phase-based gating parameters to amplitude-based parameters, enhancing treatment planning.