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Related Experiment Video

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models.

Na Rae Shin¹, Shambhunath Bose², Jing-Hua Wang¹

¹Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|May 2, 2020

Summary

Thyroid dysfunction alters gut microbiota composition. Specific bacteria like Ruminococcus and S24-7 show altered abundance in hyperthyroidism and hypothyroidism, respectively, impacting host health.

Keywords:

gut microbiota hyperthyroidism hypothyroidism thyroid function thyroidectomy

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Last Updated: Dec 22, 2025

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Area of Science:

Endocrinology and Microbiology
Investigates the interplay between hormonal regulation and microbial ecosystems.

Background:

Thyroid hormones are crucial for metabolic regulation.
The connection between thyroid function and gut microbial communities remains unclear.

Purpose of the Study:

To explore the association between thyroid dysfunction and gut microbiota composition.
To identify specific microbial changes related to hyperthyroidism and hypothyroidism.

Main Methods:

Fecal samples from rat models of hyperthyroidism and hypothyroidism were analyzed using 16S rRNA gene sequencing.
Metagenomics analysis identified bacterial populations and their relative abundance.

Main Results:

Thyroid dysfunction significantly altered gut microbial composition.
Ruminococcus abundance increased in hyperthyroidism; S24-7 increased in hypothyroidism.
Prevotellaceae and Prevotella populations decreased in hypothyroidism.

Conclusions:

Thyroid function influences gut microbiota profiles.
These findings provide a basis for studying thyroid-gut microbiome interactions.