Related Experiment Video
Updated: Dec 22, 2025
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
Published on: March 23, 2022
[Lung organoids]
Chloé Bourguignon1, Charlotte Vernisse2, Joffrey Mianné1
1IRMB, Univ Montpellier, CHU de Montpellier, Hôpital Saint Eloi, Inserm, 80 avenue Augustin Fliche, 34295 Montpellier, France.
Abstract:
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions of the respiratory epithelium with inserts in air/liquid interface (2D) or in organoids able to mimic up to the arborescence of the respiratory tree (3D). Recent development in the fields of pluripotent stem cells-derived organoids and genome editing technologies has provided new insights to better understand pulmonary diseases and to find new therapeutic perspectives.
