Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Switching Biologics in Severe Asthma: Cautionary Lessons from NIMBLE.

American journal of respiratory and critical care medicine·2026
Same author

Severe asthma and remission prospects in Europe (SHARP): insights from a multicentre observational study based on the European Severe Asthma Registry.

The Lancet. Respiratory medicine·2026
Same author

The AIM4 Next Step study: Comparing inhaled corticosteroid dose escalation to dupilumab in patients with uncontrolled asthma and type 2 inflammation.

The journal of allergy and clinical immunology. Global·2026
Same author

Educational Intervention on Environmentally Responsible Inhaler Prescribing Among French General Practitioners: Pilot Pre-Post Study.

JMIR formative research·2026
Same author

Complex interplay between disease and aerobic exercise training on vascular function in an exacerbated emphysema rat model.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Reply to Zhao et al.: Clarifying Structural - Functional Coupling by FeNO Status in VESTIGE.

American journal of respiratory and critical care medicine·2026
Same journal

[CREPT: An ally of immunotherapy for the fight against non-small-cell lung cancers].

Medecine sciences : M/S·2026
Same journal

[A new regulatory mechanism of HIF-1α: the ROS-ATM-CHK2 axis at the core of tumor angiogenesis].

Medecine sciences : M/S·2026
Same journal

[Vibrio-host interactions: from the environmental niche to virulence].

Medecine sciences : M/S·2026
Same journal

[RcsF, hyperconnected sentinel of the bacterial envelope].

Medecine sciences : M/S·2026
Same journal

[Single-cell RNA-sequencing: shattering the clone myth].

Medecine sciences : M/S·2026
Same journal

[No, Physarum blobs do not have 720 sexes!]

Medecine sciences : M/S·2026
See all related articles

Related Experiment Video

Updated: Dec 22, 2025

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

9.4K

[Lung organoids].

Chloé Bourguignon1, Charlotte Vernisse2, Joffrey Mianné1

  • 1IRMB, Univ Montpellier, CHU de Montpellier, Hôpital Saint Eloi, Inserm, 80 avenue Augustin Fliche, 34295 Montpellier, France.

Medecine Sciences : M/S
|May 2, 2020
PubMed
Summary
This summary is machine-generated.

Improving in vitro lung models is crucial for understanding chronic respiratory diseases. Advanced 2D and 3D models using stem cells and genome editing offer new therapeutic insights.

More Related Videos

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.1K
Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.8K

Related Experiment Videos

Last Updated: Dec 22, 2025

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

9.4K
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.1K
Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.8K

Area of Science:

  • Pulmonary medicine and regenerative biology.

Background:

  • Chronic respiratory diseases pose a growing global health challenge.
  • Accurate in vitro lung models are needed to study pulmonary architecture and gas exchange.
  • Existing models include 2D air/liquid interface cultures and 3D organoids.

Purpose of the Study:

  • To highlight the importance of advanced in vitro lung models for respiratory disease research.
  • To discuss the role of stem cell-derived organoids and genome editing in pulmonary research.

Main Methods:

  • Review of current in vitro lung modeling techniques (2D and 3D).
  • Discussion of pluripotent stem cell-derived organoids.
  • Integration of genome editing technologies.

Main Results:

  • In vitro lung models, particularly 3D organoids, increasingly mimic respiratory tree complexity.
  • Stem cell technologies and genome editing enhance disease modeling capabilities.
  • These advancements provide new avenues for understanding and treating lung diseases.

Conclusions:

  • Advanced in vitro lung models are essential for tackling the rising burden of respiratory diseases.
  • Pluripotent stem cells and genome editing are key to developing sophisticated models for novel therapeutic strategies.