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Published on: January 27, 2019
Application of probiotics in adjuvant treatment of infant allergic rhinitis: A randomized controlled study
Xueqiu Cao1,2, Ping Zhong1, Gang Li1
1Hearing Center/Hearing and Speech Science Laboratory, Department of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu.
Insights
This study investigates if Bifidobacterium triplex probiotics can alleviate allergic rhinitis (AR) symptoms in children. The research aims to provide insights into probiotic efficacy for managing AR in young patients.
Area of Science:
- Microbiology
- Immunology
- Pediatrics
Background:
- Intestinal flora is increasingly recognized for its role in allergic diseases.
- Previous research on probiotics for allergic rhinitis (AR) has primarily focused on animal models.
Purpose of the Study:
- To investigate the efficacy of Bifidobacterium triplex probiotics in managing symptoms of allergic rhinitis in infants and young children.
- To evaluate the impact of probiotics on the immune system in the context of AR.
Main Methods:
- A randomized controlled trial design involving 60 infants and young children diagnosed with AR.
- Participants were divided into two groups: one receiving probiotics and the other a placebo.
- Outcomes measured include a comprehensive symptom drug score, rhinitis quality of life questionnaire, visual analog scale for allergy burden, and a second quality of life questionnaire.
Main Results:
- The study design is detailed, outlining the methodology for assessing probiotic effects on AR symptoms and quality of life.
- Specific quantitative results are pending the completion of the trial.
Conclusions:
- The study is a double-center, randomized trial conducted at Minda Hospital of Hubei Minzu University and West China Hospital of Sichuan University.
- The findings will contribute to understanding the therapeutic potential of probiotics for allergic rhinitis in pediatric populations.
Background:
Several studies have suggested that intestinal flora may play an important role in allergic diseases. The purpose of this study was to investigate the effect of probiotics of Bifidobacterium triplex on the symptoms of allergic rhinitis (AR). The effects of this probiotic on the immune system have been reported in some studies, but most previous studies have been in animals.
Methods/Design:
60 infants and young children with AR were randomly divided into 2 groups: probiotics/placebo group. The main outcome was the use of a comprehensive symptom drug score to assess allergy symptoms. In addition, health-related quality of life was investigated (rhinitis quality of life questionnaire). Secondary outcomes included a visual analog scale of allergy burden and a second quality of life questionnaire. This report describes the study design of a randomized controlled trial.
Discussion:
The study design described a double-center, randomized, location at the Minda Hospital of Hubei Minzu University and West China Hospital of Sichuan University, which will be focused on the study about probiotics treatment and its effect on AR symptoms.
Trial Registration:
It has been registered at http://www.chictr.org.cn/listbycreater.aspx (Identifier: ChiCTR2000031175), Registered March 22, 2020.
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