Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hongjam, an edible silkworm-derived food, attenuates steatohepatitis and fibrosis via multi-axis modulation of metabolic stress, inflammation, and fibrogenic signaling.

Frontiers in nutrition·2026

Same author

Delayed Internal Carotid Artery Pseudoaneurysm Following Endoscopic Endonasal Approach for Anterior Clinoid Process Mucocele Treated with Flow Diversion and Adjunctive Coil Embolization : A Case Report.

Journal of Korean Neurosurgical Society·2026

Same author

Targeting KITENIN signaling in cancer progression and therapeutic resistance: mechanistic insights and future directions.

Cancer cell international·2026

Same author

Synergistic Restoration of Scarred Vocal Folds Using 532 nm Laser and Fibroblast Growth Factor.

Journal of voice : official journal of the Voice Foundation·2026

Same author

Protocol for generation of brain metastasis mouse model using stereotactic intracranial tumor-derived cells and modified intracarotid injection.

STAR protocols·2026

Same author

Shuttling of RecQ helicase HIM-6 coordinates iterative cycle of unwinding, pulling, and backsliding.

Nucleic acids research·2026

Search research articles

Related Experiment Video

Updated: Dec 22, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Dural-Based Primary Central Nervous System Lymphoma with Bone Invasion.

Seung-Won Lee¹, Tae-Young Jung¹, Hee-Jo Baek²

¹Department of Neurosurgery, Chonnam National University Medical School, Chonnam National University Hospital and Chonnam National University Hwasun Hospital, Gwangju, Republic of Korea.

World Neurosurgery

|May 4, 2020

Summary

Anaplastic large cell lymphoma (ALCL) presenting as a dural-based mass with bone invasion is a rare form of primary central nervous system lymphoma (PCNSL). This case highlights a unique presentation and successful treatment in a pediatric patient.

Keywords:

Anaplastic large cell lymphoma Anaplastic lymphoma kinase Bone invasion Primary central nervous system lymphoma Radiology

More Related Videos

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Related Experiment Videos

Last Updated: Dec 22, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Area of Science:

Neuro-oncology
Pediatric oncology
Hematology

Background:

Primary central nervous system lymphoma (PCNSL) typically presents as an intraparenchymal mass.
Meningeal and bone involvement are uncommon in PCNSL.

Observation:

A 12-year-old boy presented with headache and seizures.
MRI revealed a dural-based mass with osteolytic bone changes.
Surgical resection showed a hard, dural-based tumor with necrosis and hemorrhage, invading the skull.

Findings:

Pathological examination identified large atypical cells positive for CD30, epithelial cell antigen, and anaplastic lymphoma kinase.
The final diagnosis was anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALCL).
No systemic cancer was detected.

Implications:

Central nervous system ALCL frequently involves the dura and meninges but rarely causes osteolytic bone lesions.
This case represents a rare instance of dural-based ALCL with bone invasion.
The patient achieved remission after chemotherapy, suggesting effective treatment protocols for this rare presentation.