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Published on: April 19, 2013
The Association Between Two Common Polymorphisms and Cancer Susceptibility: A Meta-Analysis
Na Li1, Zhigang Cui2, Sixuan Li1
1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, PR China.
This meta-analysis found that miR-26a-1 rs7372209 and miR-423 rs6505162 polymorphisms are linked to overall cancer susceptibility. These genetic variations may influence an individual's risk of developing cancer.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- MicroRNAs (miRNAs) are implicated in cancer development, but findings on specific polymorphisms remain inconsistent.
- Genetic variations in miRNAs, such as miR-26a-1 rs7372209 and miR-423 rs6505162, are being investigated for their role in cancer susceptibility.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between miR-26a-1 rs7372209 and miR-423 rs6505162 polymorphisms and cancer risk.
- To provide more accurate results regarding the impact of these specific miRNA polymorphisms on overall cancer susceptibility.
Main Methods:
- A systematic literature search was performed across multiple databases (PubMed, Web of Science, Wanfang, CNKI) up to May 3, 2019.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the relationship between the polymorphisms and cancer risk.
- Statistical analyses were conducted using Stata 12.0 software, including 35 eligible articles with 17,746 cases and 21,808 controls.
Main Results:
- The miR-26a-1 rs7372209 polymorphism showed a significant association with overall cancer susceptibility in homozygote and recessive models.
- The miR-423 rs6505162 polymorphism was significantly associated with overall cancer susceptibility across multiple genetic models, except for the homozygote model.
Conclusions:
- The rs7372209 polymorphism in miR-26a-1 is associated with increased overall cancer susceptibility.
- The rs6505162 polymorphism in miR-423 is associated with altered overall cancer susceptibility.
- These findings highlight the potential role of specific miRNA genetic variations in cancer risk.
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