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P2X7 receptor antagonists for the treatment of systemic inflammatory disorders

Christine F Gelin1, Anindya Bhattacharya2, Michael A Letavic1

  • 1Discovery Chemistry, Discovery Sciences, Janssen Research and Development, LLC, San Diego, CA, United States.

Progress in Medicinal Chemistry
|May 5, 2020
PubMed

Keywords:
AmideAntagonistCNS penetrantCarboxamideDepressionIL-1βInflammatory disordersNeurodegenerative disordersP2X7PET ligand

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