Biophysical screening and characterisation in medicinal chemistry

Area of Science:

• Drug discovery and development
• Biophysical chemistry
• Medicinal chemistry

Background:

• Biophysical assays and methods have seen significant growth in medicinal chemistry over the past 20 years.
• This rise is driven by the need to address novel drug targets and modalities.
• The demand for early and accurate data on affinities, kinetics, thermodynamics, and structures fuels innovation.

Conclusions:

• Biophysical assays are indispensable tools in modern medicinal chemistry.
• Understanding the principles and limitations of each method is key to successful drug discovery.
• Emerging techniques promise further advancements in characterizing drug-target interactions.