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Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease

Wei Wang1, Xian-Tao Song1, Yun-Dai Chen2

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Journal of Geriatric Cardiology : JGC
|May 5, 2020
PubMed

Insights

Higher levels of Growth Differentiation Factor-15 (GDF-15) predict future cardiovascular events in patients with intermediate coronary artery disease (CAD). This finding highlights GDF-15 as a valuable biomarker for risk assessment in this population.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Clinical Research

Background:

  • Growth Differentiation Factor-15 (GDF-15) is implicated in processes related to coronary artery disease (CAD).
  • The predictive value of GDF-15 for future ischemic events in patients with intermediate CAD remains largely uncharacterized.
  • Understanding GDF-15's role is crucial for risk stratification in intermediate CAD.

Purpose of the Study:

  • To investigate plasma GDF-15 as a potential risk biomarker for future cardiovascular events.
  • To assess the association between GDF-15 levels and major adverse cardiac events (MACE) in patients with intermediate CAD.

Main Methods:

  • A prospective study involving 541 patients with intermediate CAD (stenosis 20%-70%).
  • Plasma GDF-15 levels were measured in a blinded fashion.
  • The primary endpoint was MACE, defined as a composite of all-cause death, nonfatal myocardial infarction, revascularization, and angina-related readmission.

Main Results:

  • After a median follow-up of 64 months, MACE occurred in 134 patients (26.6%).
  • Patients experiencing ischemic events had significantly higher plasma GDF-15 levels (median 1172.02 pg/mL vs. 965.25 pg/mL, P = 0.014).
  • Elevated GDF-15 levels were independently associated with an increased incidence of MACE (HR = 1.244, P = 0.013) after adjusting for traditional risk factors.

Conclusions:

  • Higher plasma GDF-15 levels serve as an independent predictor of long-term adverse cardiovascular events.
  • GDF-15 is a valuable prognostic biomarker for patients with intermediate coronary artery disease.
Abstract

Keywords:
Growth differentiation factor-15Intermediate coronary artery diseasePrognosis

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