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Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

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Related Experiment Video

Updated: Dec 22, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

A Supramolecular Platform Technology for Bacterial Cell Surface Modification.

Nikolas Duszenko^1,2, Danny M van Willigen², Mick M Welling²

¹Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands.

ACS Infectious Diseases

|May 5, 2020

Summary

This summary is machine-generated.

Researchers developed a new platform to modify bacterial surfaces, aiding the study of immune cell interactions and potential new therapies against antimicrobial resistance.

Keywords:

bacteria immune response infectious disease supramolecular chemistry surface modification

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Last Updated: Dec 22, 2025

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Area of Science:

Microbiology
Immunology
Biotechnology

Background:

Antimicrobial resistance necessitates novel therapeutic targets.
Understanding bacteria-immune system interactions is crucial for combating infections.
Bacterial surface composition influences recognition by immune cells like macrophages.

Purpose of the Study:

To investigate the role of bacterial surface composition in immune recognition.
To develop a platform for controlled alteration of bacterial surfaces.
To assess the impact of modified surfaces on macrophage phagocytosis and signaling.

Main Methods:

Development of a platform technology using versatile chemical scaffolds.
Controlled modification of bacterial surfaces (Gram-positive and Gram-negative).
Assessment of bacterial phagocytosis and subsequent immune signaling by monocyte-derived macrophages.

Main Results:

Chemical scaffolds were efficiently loaded onto diverse bacteria.
Modified bacterial surfaces did not impede macrophage phagocytosis.
Immune signaling by macrophages remained functional after bacterial interaction.

Conclusions:

The developed platform is a valuable tool for studying bacterial surface roles in disease.
This technology can aid in discovering new therapeutic targets for infectious diseases.
Potential applications include novel vaccination strategies using modified intact bacteria.