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Related Experiment Video

Updated: Dec 22, 2025

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

Once upon a dish: engineering multicellular systems.

Kristina Haase¹, Benjamin S Freedman²

¹EMBL Barcelona, Carrer/Dr. Aiguader 88, Barcelona 08003, Spain kristina.haase@embl.es benof@uw.edu.

Development (Cambridge, England)

|May 6, 2020

Summary

This summary is machine-generated.

Researchers met to discuss engineering multicellular systems, focusing on organoid ethics, modeling approaches, and tissue organization principles for improved biological mimicry.

Keywords:

Embryoids Morphogenesis Organ-on-chip Patterning Signaling Synthetic embryos Vascularization

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Last Updated: Dec 22, 2025

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Area of Science:

Biotechnology
Developmental Biology
Tissue Engineering

Background:

The European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) convened a global research meeting.
The meeting focused on the rapidly advancing field of engineering multicellular systems.

Purpose of the Study:

To review key themes and emerging topics in the engineering of multicellular systems.
To foster discussion on the ethical considerations and future directions in the field.

Main Methods:

A review of discussions and presentations from a global research meeting.
Synthesis of key themes including organoid ethics, modeling strategies, and tissue organization.

Main Results:

Identified critical discussion points: ethics of organoids in developmental biology.
Highlighted the debate between bottom-up and top-down modeling approaches.
Explored fundamental tissue organizing principles and strategies for enhancing system mimicry of natural biology.

Conclusions:

The engineering of multicellular systems is a dynamic field with significant ethical and technical considerations.
Future advancements require a deeper understanding of tissue organization and improved modeling techniques.
Continued interdisciplinary collaboration is essential for progress in creating more biologically relevant engineered systems.