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Updated: Dec 22, 2025
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
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COVID-19 and Avoiding Ibuprofen. How Good Is the Evidence?
Gurusaravanan Kutti Sridharan1, Rajesh Kotagiri1, Vijay H Chandiramani1
1Department of Internal Medicine, Banner University Medical Center, University of Arizona, Tucson, AZ.
American Journal of Therapeutics
|May 6, 2020
Summary
Ibuprofen, used for pain and fever, may be beneficial for COVID-19. Current evidence does not support concerns about increased risk or disease severity with ibuprofen use.
Area of Science:
- Pharmacology
- Virology
- Immunology
Background:
- Ibuprofen is a common medication for pain and fever.
- Concerns arose about ibuprofen potentially increasing ACE2 levels, a receptor for SARS-CoV-2 entry.
- This raised fears of increased COVID-19 risk or severity.
Purpose of the Study:
- To evaluate the safety and potential impact of ibuprofen use in the context of COVID-19.
- To address concerns linking ibuprofen to increased ACE2 levels and SARS-CoV-2 infection.
Main Methods:
- Review of existing literature and studies on ibuprofen and ACE2.
- Analysis of data regarding the Renin-Angiotensin-Aldosterone system and viral infections.
Main Results:
- Limited studies suggest recombinant ACE2 administration may improve lung damage in viral infections.
- Available data do not show evidence to discourage ibuprofen use for COVID-19 symptoms.
Conclusions:
- Current evidence does not support discouraging ibuprofen use during the COVID-19 pandemic.
- Ibuprofen's potential role in ACE2 modulation may warrant further investigation for therapeutic benefits.
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