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Related Experiment Video

Updated: Dec 22, 2025

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions

Published on: July 22, 2022

Functional heterogeneity in senescence.

Kristina Kirschner¹, Nattaphong Rattanavirotkul², Megan F Quince¹

¹Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, U.K.

Biochemical Society Transactions

|May 6, 2020

Summary

This summary is machine-generated.

Cellular senescence, a tumor suppressor mechanism, can spread to neighboring cells, creating functional heterogeneity. Understanding this heterogeneity is key for developing targeted senolytic therapies.

Keywords:

Notch heterogeneity secondary senescence senescence senotherapy

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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

Area of Science:

Cell Biology
Molecular Biology
Oncology

Background:

Cellular senescence acts as a tumor suppressor, triggered by cellular stress.
Senescence can propagate to nearby cells via paracrine or juxtacrine signaling, termed secondary senescence induction.
Distinct transcriptional profiles and varied phenotypes arise from primary and secondary senescence induction, influenced by cell type and stimulus.

Purpose of the Study:

To explore the functional heterogeneity of senescence.
To highlight tissue- and cell-type specific differences in senescence outcomes.
To underscore the importance of understanding senescence heterogeneity for therapeutic targeting.

Main Methods:

Review of existing literature on primary and secondary senescence.
Analysis of transcriptional outcomes and phenotypic variations.
Discussion of juxtacrine Notch signaling in secondary senescence.

Main Results:

Primary and secondary senescence induction yield distinct transcriptional results.
Senescence phenotype varies based on cell type and inducing stimulus.
Functional heterogeneity in senescence end-points remains largely unclear.

Conclusions:

Senescence exhibits functional heterogeneity across different cell types and tissues.
Differences in primary and secondary senescence outcomes contribute to this heterogeneity.
Targeting senescent cells with senolytics, senostatics, or senogenics requires understanding senescence heterogeneity.