Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

51.3K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polystyrene Microplastics Activate Noncanonical TGF‑β Signaling and Metabolomic Reprogramming to Promote Epithelial-Mesenchymal Transition and Fibrosis in the Kidney.

ACS omega·2026
Same author

Circulating metabolome as key biomarkers for ventilator-associated pneumonia: Case-Control study in a tertiary care hospital of North India.

International journal of critical illness and injury science·2026
Same author

Insights from NMR - based metabolomics elucidates key metabolic dysregulation in pancreatitis-induced acute respiratory distress syndrome: A step towards precision medicine.

Biophysical chemistry·2026
Same author

Dehydration-Induced Motional Heterogeneity in Native Collagen Protein Probed by Solid-State NMR Spectroscopy.

Biomacromolecules·2026
Same author

A review on artificial intelligence in pharmaceutical sciences: opportunities and challenges.

Drug development and industrial pharmacy·2026
Same author

Serum metabolomic profiling by <sup>1</sup>H NMR reveals distinct metabolic signatures in diabetic and non-diabetic chronic kidney disease.

Biophysical chemistry·2026

Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

1.1K

Water-lipid interactions in native bone by high-resolution solid-state NMR spectroscopy.

Nidhi Tiwari1, RamaNand Rai2, Neeraj Sinha3

  • 1Centre of Biomedical Research, SGPGIMS Campus, Raebarelly Road, Lucknow, 226014, India; Department of Chemistry, Institute of Sciences, Banaras Hindu University, Varanasi, 221005, India.

Solid State Nuclear Magnetic Resonance
|May 7, 2020
PubMed
Summary

Water content significantly impacts triglyceride dynamics within bone, influencing bone health and disease. This study reveals how hydration levels affect lipid structures, crucial for understanding bone homeostasis and disorders.

Keywords:
Bone matrixDynamicsLipidsRelaxationTriglycerides

More Related Videos

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

15.9K
Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
10:07

Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance

Published on: August 26, 2025

445

Related Experiment Videos

Last Updated: Dec 22, 2025

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

1.1K
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

15.9K
Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
10:07

Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance

Published on: August 26, 2025

445

Area of Science:

  • Biophysics
  • Bone Biology
  • Lipidomics

Background:

  • Lipid interactions within bone are vital for homeostasis, mineralization, and metabolism.
  • Understanding lipid dynamics in native bone environments is crucial for bone health research.

Purpose of the Study:

  • To investigate water-dependent dynamical changes in bone triglycerides.
  • To elucidate the role of water in stabilizing lipid structures within bone.

Main Methods:

  • Utilized high-resolution 1H solid-state nuclear magnetic resonance (ssNMR) spectroscopy.
  • Performed T2 relaxation measurements under varying hydration levels (dehydration and H/D exchange).

Main Results:

  • Observed significant changes in triglyceride dynamics correlated with hydration levels.
  • Demonstrated that water network alterations directly impact lipid local environment and dynamics within bone.

Conclusions:

  • Water plays a critical role in stabilizing the structural properties of triglycerides in bone.
  • Findings provide insights into the pathological roles of lipids in bone physiology and disorders.