Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY-32
Lu Wang1, Jieying Jiao2, Dan Liu1
1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.
Chemistry & Biodiversity
|May 7, 2020
Abstract:
Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY-32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL-60 and HO8910 cells with IC50 values of 7.54 and 20.32 μm.


