Related Experiment Video

Updated: Dec 22, 2025

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
08:41

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

Published on: April 6, 2022

3.0K

Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation

Miyong Yun1, Young-Su Yi2

  • 1Department of Bioindustry and Bioresource Engineering, Sejong University, Seoul, Republic of Korea.

Journal of Ginseng Research
|May 7, 2020
PubMed

Insights

Ginseng effectively combats inflammation by inhibiting inflammasomes and inflammatory caspases. This review explores ginseng

Area of Science:

  • Immunology and Pharmacology
  • Natural Product Medicine

Background:

  • Inflammation is a critical immune response involving inflammasome activation.
  • Inflammasomes activate inflammatory caspases (e.g., caspase-1, 4, 5, 11, 12).
  • Ginseng is a traditional herbal medicine used for inflammatory conditions.

Purpose of the Study:

  • To review the regulatory roles of ginseng on inflammatory caspases.
  • To explore ginseng's anti-inflammatory mechanisms.
  • To suggest future research directions for ginseng as an anti-inflammatory agent.

Main Methods:

  • Literature review of studies on ginseng and inflammation.
  • Analysis of ginseng's effects on inflammasome and caspase pathways.
  • Synthesis of current research on ginseng's anti-inflammatory properties.

Main Results:

  • Ginseng demonstrates significant anti-inflammatory effects.
  • Ginseng inhibits inflammasome activation and downstream inflammatory caspases.
  • Evidence supports ginseng's efficacy in inflammation-mediated diseases.

Conclusions:

  • Ginseng modulates inflammatory caspases, offering therapeutic potential.
  • Further research can optimize ginseng's use as a safe anti-inflammatory herbal medicine.
  • Ginseng presents a novel insight into natural anti-inflammatory drug development.
Keywords:
AIM2, Absent in melanoma 2ASC, Apoptosis-associated speck-like protein containing CARDCARD, C-terminal caspase recruit domainCOX-2, Cyclooxygenase-2Caspase, Cysteine aspartate–specific proteaseDAMP, Danger-associated molecular patternFIIND, Functional-to-find domainGSDMD, Gasdermin DGinsengGinsenosideHIN, Hematopoietic interferon-inducible nuclear proteinIL, InterleukinInflammasomeInflammationInflammatory caspaseLPS, LipopolysaccharideLRR, Leucine-rich repeatNACHT, Nucleotide-binding and oligomerization domainNF-κB, Nuclear factor-kappa BNLR, Nucleotide-binding oligomerization domain-like receptorNO, Nitric oxidePAMP, Pathogen-associated molecular patternPGE2, Prostaglandin E2PRR, Pattern-recognition receptorPYD, N-terminal pyrin domainRGE, Korean Red GinsengROS, Reactive oxygen species

More Related Videos

Evaluation of Caspase Activation to Assess Innate Immune Cell Death10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.7K
Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry05:29

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry

Published on: March 24, 2023

5.3K

Related Concept Videos

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
13.5K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
7.8K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
16.7K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.0K
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.6K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.5K