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Could host cell receptor alteration prevent SARS-CoV-2 viral entry? - Hype or hope
M Paulpandi1, K Kavithaa, A Asaikkutty
1Disease Proteomics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, TN, India. curlyproteomics@gmail.com.
Abstract:
Cell-surface receptors are the inviters of many potent pathogens that can adjust to any kind of circumstance for their existence. Many of these organisms are highly resistant to the currently existing drugs and mutate to new strains with high levels of pathogenesis, posing life-threatening consequences. Owing to such concerns, antiviral strategies are being assessed based on host cell receptor targeting. Many natural compounds with a tendency to strip off the cell surface receptors are under evaluation. Compounds that are non-toxic, patient friendly, and yield a quick output are essential for the current scenario. Drugs targeting the cell surface receptors should, therefore, be developed and standardized for the effective management of SARS-CoV-2 viral infection.
Insights
Targeting host cell receptors offers a novel antiviral strategy against drug-resistant pathogens like SARS-CoV-2. Developing non-toxic compounds that block these receptors is crucial for effective treatment.
Area of Science:
- Virology
- Pathogen-host interactions
- Drug discovery
Background:
- Pathogens utilize host cell surface receptors for entry and survival.
- Many pathogens exhibit drug resistance and high pathogenesis, posing significant health risks.
- Current antiviral strategies face challenges due to pathogen mutation and resistance.
Purpose of the Study:
- To evaluate antiviral strategies focused on targeting host cell receptors.
- To explore the potential of natural compounds in blocking pathogen-host receptor interactions.
- To identify essential characteristics for new antiviral drug development, including non-toxicity and rapid efficacy.
Main Methods:
- Assessment of antiviral strategies based on host cell receptor targeting.
- Evaluation of natural compounds that can disrupt cell surface receptor binding.
- Analysis of compound characteristics such as toxicity, patient-friendliness, and speed of action.
Main Results:
- Host cell receptor targeting is a promising antiviral approach.
- Natural compounds show potential for stripping cell surface receptors.
- The need for non-toxic, patient-friendly compounds with rapid action is highlighted.
Conclusions:
- Host cell receptor targeting presents a viable strategy for managing viral infections.
- Development and standardization of drugs targeting cell surface receptors are essential for effective treatment.
- This approach is particularly relevant for managing infections like SARS-CoV-2.
