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Thrombospondin-1 in maladaptive aging responses: a concept whose time has come.
Jeffrey S Isenberg1, David D Roberts2
1Radiation Control Technologies, Inc., Loudonville, New York.
American Journal of Physiology. Cell Physiology
|May 7, 2020
Summary
Thrombospondin-1 (TSP1) promotes aging and age-related diseases when chronically accumulated. Targeting TSP1's maladaptive roles may offer therapies to delay aging.
Area of Science:
- Gerontology
- Molecular Biology
- Biochemistry
Background:
- Aging involves molecular and cellular changes across systems.
- The secreted protein thrombospondin-1 (TSP1) has roles in youth but contributes to aging when chronic.
Purpose of the Study:
- To investigate thrombospondin-1 (TSP1) as a promoter of aging and age-related diseases.
- To explore the chronic accumulation of TSP1 in the extracellular matrix as a maladaptive aging factor.
Main Methods:
- Review of accumulating basic and clinical data on TSP1.
- Analysis of TSP1's physiological functions in youth versus chronic disease states.
Main Results:
- Chronic accumulation of TSP1 in the extracellular matrix is linked to aging.
- TSP1's acute functions in youth contrast with its maladaptive roles in aging.
Conclusions:
- Chronic TSP1 accumulation is a significant contributor to the aging process.
- Identifying TSP1-producing cells and mechanisms could lead to therapies for age-related diseases.
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