Synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives

Furo[3,4-d]pyrimidine was obtained in the reaction of 2-phenyl-4-phenylamino-6-methyl-5-pyrimidinecarboxylic acid with SOCl2. This compound, heated with aliphatic amines, yielded mono- and diamino-derivatives. Some of the obtained compounds exhibited a potent antineoplastic activity.