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Related Experiment Video

Updated: Dec 22, 2025

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization

Gabriella Captur1,2,3, Abhiyan Bhandari4, Rüdiger Brühl5

  • 1UCL Institute of Cardiovascular Science, University College London, Gower Street, London, WC1E 6BT, UK.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|May 8, 2020
PubMed
Summary

The T1MES phantom ensures T1 mapping quality assurance across centers. Despite variations in field strength and sequences, specific scanner and sequence combinations show high repeatability for clinical use.

Keywords:
CalibrationExtracellular volumePhantomRepeatabilityStandardizationT1 mapping

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Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Quality Assurance

Background:

  • The T1MES (T1 Mapping and Extracellular volume Standardization) program utilized a CE/FDA-cleared phantom for T1 mapping quality assurance.
  • This study aimed to assess T1 measurement repeatability across different centers, evaluating sequence, magnet, and vendor performance.

Purpose of the Study:

  • To evaluate the repeatability of T1 mapping measurements across multiple centers using a standardized phantom.
  • To identify factors influencing T1 measurement variability, including field strength, scanner type, and sequence parameters.

Main Methods:

  • Utilized batch-manufactured phantoms over two years for structural imaging, B0 and B1 testing, and reference T1 measurements.
  • Assessed center-specific T1 mapping repeatability on 1.5T and 3T magnets using various T1 mapping sequences over extended periods.
  • Analyzed image and temperature data, evaluating repeatability using coefficient of variation (CoV) and constructing linear mixed models.

Main Results:

  • Phantom integrity and reference T1 values remained stable over two years.
  • T1 measurements showed temperature dependency, with varying effects based on field strength and sequence.
  • High repeatability (mean CoV < 1-2%) was observed for many sequences/magnets, with narrower ranges for 1.5T compared to 3T.
  • T1 mapping sequence and scanner software version were significant factors influencing T1 variation across centers.

Conclusions:

  • The T1MES phantom is a reliable tool for multi-center T1 mapping quality assurance.
  • While performance differences exist across field strengths, sequences, and manufacturers, specific combinations demonstrate high repeatability.
  • Standardized T1 assessment for clinical use is feasible with certain scanner/sequence combinations, though temperature correction is necessary.