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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Clinicopathologic Differences Between Micropapillary and Papillary Thyroid Carcinoma.

Kinyas Kartal1, Nurcihan Aygün2, Mehmet Uludağ2

  • 1Department of General Surgery, Koc University Hospital, Istanbul, Turkey.

Sisli Etfal Hastanesi Tip Bulteni
|May 8, 2020
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Summary
This summary is machine-generated.

Thyroid papillary microcarcinomas (PTMs) often have good prognoses, but risks like multifocality and extrathyroidal extension are present. Careful follow-up is crucial for PTM patients with these specific histopathological features.

Keywords:
Extrathyroidal extensionlymph node metastasislymphovascular invasionprognosisthyroid micropapillary carcinomathyroid papillary carcinoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Thyroid papillary microcarcinomas (PTMs) are small tumors (<1 cm) within the broader category of papillary thyroid carcinoma (PTC).
  • Understanding the clinicopathologic differences between PTMs and larger PTCs is essential for appropriate patient management and prognosis.

Purpose of the Study:

  • To observe the clinicopathologic features of PTMs.
  • To compare these features with those of larger papillary thyroid carcinomas (PTCs).

Main Methods:

  • Retrospective analysis of 86 surgically treated PTC patients.
  • Group 1 (G1): tumors <1 cm (PTMs). Group 2 (G2): tumors >1 cm (PTCs).
  • Comparison of clinicopathologic factors including tumor size, multicentricity, lymphovascular invasion, extrathyroidal extension, and lymph node metastasis.

Main Results:

  • No significant difference in preoperative TSH, anti-TPO, or TgAb levels between groups.
  • G2 demonstrated significantly higher rates of multicentricity (66% vs 36%), lymphovascular invasion (61% vs 14.2%), extrathyroidal extension (63.6% vs 21.4%), central lymph node metastasis (38.6% vs 4.8%), and lateral lymph node metastasis (20.5% vs 0%) compared to G1.
  • All comparisons between G1 and G2 showed statistically significant differences (p<0.001).

Conclusions:

  • While PTMs generally exhibit favorable prognostic factors and high survival rates, certain aggressive features are not uncommon.
  • Risk factors such as multifocality, extrathyroidal extension, and lymphovascular invasion, which increase recurrence risk, can be present in PTMs.
  • Patients with PTMs exhibiting these histopathological risk factors require more vigilant clinical follow-up.