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Platelet Count and Mean Platelet Volume in Psoriasis Patients
Ezgi Özkur1, Sıla Şeremet2, Fatma Şule Afşar2
1Department of Dermatology, University of Health Sciences, Sisli Hamidiye Etfal Traning and Research Hospital, Istanbul, Turkey.
Sisli Etfal Hastanesi Tip Bulteni
|May 8, 2020
Summary
Platelet count and mean platelet volume (MPV) are elevated in psoriasis patients, indicating platelets play a role in this chronic inflammatory disease. These markers may help assess treatment outcomes.
Area of Science:
- Dermatology
- Hematology
- Immunology
Background:
- Psoriasis is a chronic, immune-mediated inflammatory disease.
- Platelets are implicated in the pathogenesis of psoriasis.
- Mean platelet volume (MPV) serves as an indicator of platelet activation.
Purpose of the Study:
- To investigate MPV levels and platelet count in psoriasis patients.
- To assess the association between these hematologic parameters and psoriasis severity.
Main Methods:
- A case-control study was conducted with 28 psoriasis patients and 30 healthy controls.
- Hematologic parameters and sedimentation rates were compared between groups.
- Parameters were correlated with the Psoriasis Area and Severity Index (PASI) score.
Main Results:
- Psoriasis patients exhibited significantly higher MPV and platelet counts compared to controls (p=0.012, p=0.015).
- Platelet count showed a positive correlation with PASI scores (r=0.424, p=0.025).
- No statistically significant difference in sedimentation rate was observed between groups.
Conclusions:
- Elevated MPV and platelet counts in psoriasis patients suggest a significant role for platelets in the disease's pathophysiology.
- These findings may offer insights into assessing treatment efficacy in psoriasis.
- Further research is warranted to clarify the complex relationship between hematologic parameters and psoriasis.
