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Preoperative Systemic Coagulation Inflammation Index may be a Predictor of Worse Outcomes After Carotid

Mesut Engin1, Orhan Guvenc1, Ahmet Kagan As1

  • 1Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Türkiye.

Sisli Etfal Hastanesi Tip Bulteni
|July 10, 2026
PubMed

Insights

High systemic coagulation inflammation index (SCII) values predict worse outcomes after carotid endarterectomy (CEA) surgery. Preoperative SCII assessment can identify high-risk patients for improved postoperative management.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Inflammation and Immunology

Background:

  • Stroke is a leading cause of mortality and morbidity, with carotid artery stenosis (CAS) as a primary contributor.
  • Carotid endarterectomy (CEA) remains a key surgical intervention for CAS, despite advances in endovascular treatments.
  • The systemic coagulation inflammation index (SCII) is a recognized marker for assessing coagulation and inflammatory status.

Purpose of the Study:

  • To evaluate the association between SCII values and adverse outcomes within 30 days following CEA.
  • To identify SCII as a potential predictor of postoperative complications in patients undergoing CEA.

Main Methods:

  • A retrospective analysis of 594 patients undergoing elective CEA between January 2020 and June 2025.
  • Patients were categorized into two groups: Group 1 (no worse outcomes) and Group 2 (worse outcomes: stroke, myocardial infarction, or death).
  • Multivariate analysis was employed to identify independent predictors of worse outcomes.

Main Results:

  • High SCII values (OR: 1.780, 95% CI: 1.270-2.894, p<0.001) were identified as an independent predictor of worse outcomes post-CEA.
  • Coronary artery disease was also a significant predictor (OR: 1.690, 95% CI: 1.210-1.984, p=0.032).
  • 48 patients experienced worse outcomes, while 546 did not.

Conclusions:

  • Elevated SCII levels are significantly associated with adverse 30-day outcomes after CEA.
  • Preoperative SCII measurement can aid in identifying patients at higher risk for postoperative complications.
  • This information can guide proactive patient management and follow-up strategies post-CEA.
Abstract

Keywords:
Carotid arterycoagulationinflammationmorbiditysurgery

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