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Microscopic susceptibility anisotropy imaging.

Enrico Kaden^1,2, Noemi G Gyori^1,2, S Umesh Rudrapatna³

¹Centre for Medical Image Computing, University College London, London, UK.

Magnetic Resonance in Medicine

|May 8, 2020

Summary

This summary is machine-generated.

This study introduces microscopic susceptibility anisotropy imaging to map brain tissue microstructure. The novel method disentangles magnetic susceptibility from fiber orientation, improving microstructural integrity assessment.

Keywords:

brain white matter gradient-echo MR imaging microscopic frequency shift orientational tissue heterogeneity spherical mean technique (SMT)

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Area of Science:

Neuroimaging
Biophysics
Materials Science

Background:

Gradient-echo MRI signals in brain white matter are influenced by fiber orientation relative to the magnetic field.
Accurate mapping of microstructure-specific magnetic susceptibility requires accounting for orientation effects.

Purpose of the Study:

To develop a novel framework for mapping microscopic susceptibility anisotropy in heterogeneous brain tissue.
To disentangle tissue magnetic susceptibility from axon orientation effects in gradient-echo MRI.

Main Methods:

Introduced microscopic susceptibility anisotropy imaging (MSAI).
Utilized diffusion MRI data to infer orientational tissue structure.
Factored out magnetic field direction dependence from frequency difference signals.

Main Results:

Demonstrated proxy maps of microscopic susceptibility anisotropy in a human pilot study.
Results were unconfounded by fiber crossings, orientation dispersion, and magnetic field direction.
The technique requires dual-echo gradient-echo scans and a 2-shell diffusion protocol.

Conclusions:

Quantitative recovery of microscopic susceptibility features is improved.
The method enhances the assessment of microstructural tissue integrity in the presence of orientational heterogeneity.