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Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events
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An Internal Dial for Sensitivity and Gain of Rapid Mechanotransduction
1Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Neuron
|May 8, 2020
Abstract:
Piezos are ion channels that are activated by mechanical force. Now, 10 years after their initial discovery, Geng et al. (2020) reports, in this issue of Neuron, a novel Piezo1 variant with distinct functional properties, providing key insights into Piezo's structure and function that were fully unexpected.
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