Generation of indole derivatives by an endophytic fungus Chaetomium sp. through feeding 1,2-dimethylindole
Xiaoqi Jin1, Haoran Ma2, Fuqian Wang2
1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
Abstract:
Through feeding 1,2-dimethylindole, two new bisindoles, chaetoindolone E and F (1 and 2) and five known indole derivatives (3-7) were isolated from the cultures of an endophytic fungus Chaetomium sp. The structures of these compounds were elucidated based on HR-MS, NMR and single-crystal X-ray crystallography. Compounds 1 and 2 were undescribed before, compounds 3-7 were first reported from natural sources, and NMR spectrums of compounds 4 and 5 were first reported. The cytotoxity of the bisindole compounds (1-3) was also tested.
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