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Related Experiment Video

Updated: Dec 22, 2025

An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
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The TELL automatic sample changer for macromolecular crystallography.

Isabelle Martiel1, Dominik Buntschu1, Nathalie Meier1

  • 1Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, Switzerland.

Journal of Synchrotron Radiation
|May 9, 2020
PubMed
Summary
This summary is machine-generated.

The TELL sample exchange system enhances macromolecular crystallography by offering high throughput, speed, and reliability. This automated system supports multiple beamlines for efficient data collection.

Keywords:
cryogenic sample handlinghigh-throughputmacromolecular crystallographysample changers

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Area of Science:

  • Structural Biology
  • Biophysics
  • Materials Science

Background:

  • Macromolecular crystallography requires efficient sample handling for high-throughput data collection.
  • Existing sample exchange systems may face limitations in speed, capacity, or reliability.

Purpose of the Study:

  • To present the design and functionalities of the TELL sample exchange system.
  • To highlight the system's development at the Paul Scherrer Institute.
  • To detail its application in serving macromolecular crystallography beamlines.

Main Methods:

  • Design and implementation of the TELL system.
  • Focus on optimizing speed, storage capacity, and reliability.
  • Integration with existing synchrotron infrastructure.

Main Results:

  • The TELL system provides high-throughput sample exchange capabilities.
  • Demonstrated reliability and efficiency in serving multiple beamlines.
  • Successful integration with the Swiss Light Source and SwissFEL.

Conclusions:

  • The TELL system represents a significant advancement in automated sample handling for macromolecular crystallography.
  • Its design addresses key requirements for modern structural biology research.
  • The system enhances the efficiency and capacity of X-ray diffraction experiments.