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Updated: Dec 22, 2025

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Published on: May 9, 2018
Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants
Stanislas Grassin-Delyle1,2, Hélène Salvator1,3, Marion Brollo3
1Department of Respiratory Diseases, Foch Hospital, Suresnes, France.
Abstract:
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
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