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Phase-Change Materials for Controlled Release and Related Applications.

Jichuan Qiu1, Da Huo1, Younan Xia1,2

  • 1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.

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Summary

Phase-change materials (PCMs) offer controlled release of encapsulated payloads upon melting. This review highlights advances in using PCMs, particularly fatty acids and alcohols, for therapeutic delivery systems.

Keywords:
controlled releasefatty acidsphase-change materialsstimuli-responsive drug delivery

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Drug Delivery

Background:

  • Phase-change materials (PCMs) are thermo-responsive solids that transition to liquids, enabling payload release.
  • Recent advances focus on PCMs for controlled delivery of therapeutic agents and biological effectors.
  • Fatty acids and fatty alcohols are emphasized due to their favorable properties like low toxicity and biodegradability.

Purpose of the Study:

  • To review the progress in utilizing PCMs for encapsulation and controlled release applications over the past decade.
  • To provide an overview of PCMs, their properties, and processing methods for controlled release.
  • To discuss the applications and future prospects of PCM-based delivery systems.

Main Methods:

  • Review of literature on phase-change materials for controlled release applications.
  • Analysis of processing techniques for creating PCM-payload suspensions.
  • Discussion of various triggers for inducing the solid-to-liquid phase transition in PCMs.

Main Results:

  • PCMs provide a versatile platform for encapsulating and releasing diverse therapeutic agents.
  • Fatty acids and fatty alcohols are cost-effective, biodegradable, and readily available PCM options.
  • Established methods exist for processing PCMs and triggering their phase transition for payload release.

Conclusions:

  • PCM-based systems represent a promising approach for advanced drug delivery and controlled release applications.
  • Further research into PCM optimization and diverse applications is warranted.
  • The inherent properties of PCMs, especially fatty acids and alcohols, support their use in biomedical fields.