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Polymeric Nanoparticles for Brain Drug Delivery - A Review
Subashini Raman1, Syed Mahmood1, Ayah R Hilles2
1Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300, Kuantan, Pahang, Malaysia.
Current Drug Metabolism
|May 9, 2020
Summary
Polymeric nanoparticles show promise for brain drug delivery by overcoming the blood-brain barrier. Surface modification is key to enhancing nanoparticle targeting and therapeutic efficacy.
Area of Science:
- Nanomedicine
- Materials Science
- Pharmacology
Background:
- The blood-brain barrier (BBB) significantly impedes drug delivery to the brain.
- Nanoparticle-based approaches are actively being developed to improve brain drug targeting.
- Polymeric nanoparticles are widely explored for spatial and temporal targeted drug delivery.
Purpose of the Study:
- To review the formulation and properties of polymeric nanoparticles for brain drug delivery.
- To explore the impact of surface modification on nanoparticle characteristics and brain targeting.
- To provide an overview of nanomedicines used to cross the BBB and their biodistribution.
Main Methods:
- Non-systematic literature review using Google, Science Direct, and PubMed.
- Overview of polymeric nanoparticle formulation methods and surface modification effects.
- Analysis of nanomedicines for BBB penetration and drug biodistribution.
Main Results:
- Various polymeric nanoparticle systems effectively deliver therapeutic agents to targeted brain areas.
- Physicochemical properties (size, shape, elasticity, charge, hydrophobicity) influence nanoformulation outcomes.
- Surface modification of nanoparticles is crucial for enhancing brain targeting efficiency.
Conclusions:
- Standardized methods for nanoparticle preparation and surface modification assessment are needed.
- Further research is required to optimize nanoparticle properties (drug loading, size, charge, permeation) for consistent brain delivery.
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