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Related Experiment Video

Updated: Dec 22, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Lower urinary tract dysfunction in common neurological diseases.

Mohamad Moussa¹, Athanasios Papatsoris², Mohamed Abou Chakra¹

¹Department of Urology, Al Zahraa University Medical Center, Beirut, Lebanon.

Turkish Journal of Urology

|May 9, 2020

Summary

This summary is machine-generated.

Neurological disorders can cause lower urinary tract dysfunction (LUTD), leading to symptoms like impaired storage and voiding. Management strategies for neurogenic LUTD range from self-catheterization to medications and botulinum toxin injections.

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Area of Science:

Neurology
Urology
Nephrology

Background:

The lower urinary tract's function of urine storage and voiding relies on intact nerve supply.
Neurological disorders frequently disrupt this nerve supply, resulting in lower urinary tract dysfunction (LUTD) and symptoms (LUTS).

Purpose of the Study:

To provide a comprehensive overview of the clinical characteristics, diagnosis, and management of LUTD in patients with common central and peripheral neurological diseases.

Main Methods:

Review of clinical characteristics, diagnostic approaches, and therapeutic interventions for neurogenic LUTD.
Inclusion of common neurological conditions such as spinal cord injury, multiple sclerosis, Parkinson's disease, diabetes mellitus, and others.
Assessment involves clinical evaluation, laboratory tests, imaging, and urodynamic studies.

Main Results:

LUTD pathophysiology varies based on the neurological disease's onset.
Impaired voiding often managed with clean intermittent self-catheterization (if postvoid residual urine >100 ml).
Storage symptoms typically managed with antimuscarinic medications; botulinum toxin type A shows promise for refractory neurogenic detrusor overactivity.

Conclusions:

LUTD is a significant complication of various neurological disorders.
Effective management requires accurate diagnosis and tailored treatment strategies.
Emerging treatments like botulinum toxin offer new hope for complex cases.