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Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples
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Qualification of Non-Halogenated Organic Solvents Applied to Microsphere Manufacturing Process.

Hyunjin Shim1, Hongkee Sah1

  • 1College of Pharmacy, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 03760, Korea.

Pharmaceutics
|May 10, 2020
PubMed
Summary

Ethyl formate offers a superior alternative to ethyl acetate for manufacturing poly-lactic-co-glycolic acid (PLGA) microspheres. This new method enhances drug encapsulation, size uniformity, and reduces residual solvents in PLGA drug delivery systems.

Keywords:
microencapsulationmicrospherespoly-d,l-lactide-co-glycolidesolvent qualification

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Chemical Engineering

Background:

  • Ethyl acetate is the standard solvent for poly-lactic-co-glycolic acid (PLGA) microsphere production.
  • Current ethyl acetate-based methods have limitations impacting microsphere quality.

Purpose of the Study:

  • To evaluate ethyl formate as a viable alternative solvent for PLGA microsphere fabrication.
  • To compare the performance of ethyl formate and ethyl acetate in encapsulating a hydrophobic drug.

Main Methods:

  • An oil-in-water emulsion solvent extraction technique was employed.
  • Progesterone was encapsulated into PLGA microspheres using both solvents.
  • Process parameters were adjusted to control droplet properties and microsphere characteristics.

Main Results:

  • Ethyl formate demonstrated better volatility and water miscibility compared to ethyl acetate.
  • PLGA microspheres produced with ethyl formate exhibited improved drug crystallization and encapsulation efficiency.
  • Ethyl formate resulted in more homogeneous microsphere size and lower residual solvent content.

Conclusions:

  • Ethyl formate is a promising solvent for producing high-quality PLGA microspheres.
  • The developed ethyl formate-based technique offers advantages for drug-loaded microsphere manufacturing.
  • This method presents an attractive alternative for pharmaceutical applications.